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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSEN1 All Species: 13.94
Human Site: T354 Identified Species: 23.59
UniProt: P49768 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49768 NP_000012.1 467 52668 T354 H L G P H R S T P E S R A A V
Chimpanzee Pan troglodytes XP_001149972 443 50485 R340 D V C N P Q W R G H P E W E W
Rhesus Macaque Macaca mulatta XP_001088524 384 43068 L281 S R A A V Q E L S S S I L A G
Dog Lupus familis XP_547503 717 78133 E591 L Q L P Y D P E M E E D S Y D
Cat Felis silvestris
Mouse Mus musculus P49769 467 52621 T354 H L G P H R S T P E S R A A V
Rat Rattus norvegicus P97887 468 52771 T355 H L G P H R S T P E S R A A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514754 455 50711 L352 P A N L P A Y L V E E V E E E
Chicken Gallus gallus Q4JIM4 468 52812 T355 R I G P I E S T P E S R A A V
Frog Xenopus laevis O12976 433 48282 L330 S R V A V Q A L P S N S P P S
Zebra Danio Brachydanio rerio Q9W6T7 456 50963 Q347 S T E E S R R Q I Q E M P S A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02194 541 59286 D375 H P R Q N Q R D D G S V L A T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52166 444 50016 P341 R E L A A E R P T V Q D A N F
Sea Urchin Strong. purpuratus XP_001178715 518 58077 S395 D L E R S A N S S V T S E D R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O64668 453 49290 N347 E L M G W G D N R E E A R G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.7 82.2 46.2 N.A. 92.7 92.5 N.A. 62.3 82.2 77.3 70.8 N.A. 47.6 N.A. 49 55.6
Protein Similarity: 100 90.7 82.2 52 N.A. 96.5 96.5 N.A. 73.6 89.7 83 79 N.A. 63.4 N.A. 64 68.1
P-Site Identity: 100 0 13.3 13.3 N.A. 100 100 N.A. 6.6 73.3 6.6 6.6 N.A. 20 N.A. 6.6 6.6
P-Site Similarity: 100 13.3 20 26.6 N.A. 100 100 N.A. 6.6 80 26.6 20 N.A. 33.3 N.A. 6.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 20.3 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.5 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 22 8 15 8 0 0 0 0 8 36 43 8 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 0 0 0 0 8 8 8 8 0 0 15 0 8 8 % D
% Glu: 8 8 15 8 0 15 8 8 0 50 29 8 15 15 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 29 8 0 8 0 0 8 8 0 0 0 8 8 % G
% His: 29 0 0 0 22 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 8 0 0 8 0 0 0 8 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 36 15 8 0 0 0 22 0 0 0 0 15 0 8 % L
% Met: 0 0 8 0 0 0 0 0 8 0 0 8 0 0 0 % M
% Asn: 0 0 8 8 8 0 8 8 0 0 8 0 0 8 0 % N
% Pro: 8 8 0 36 15 0 8 8 36 0 8 0 15 8 0 % P
% Gln: 0 8 0 8 0 29 0 8 0 8 8 0 0 0 0 % Q
% Arg: 15 15 8 8 0 29 22 8 8 0 0 29 8 0 8 % R
% Ser: 22 0 0 0 15 0 29 8 15 15 43 15 8 8 8 % S
% Thr: 0 8 0 0 0 0 0 29 8 0 8 0 0 0 8 % T
% Val: 0 8 8 0 15 0 0 0 8 15 0 15 0 0 29 % V
% Trp: 0 0 0 0 8 0 8 0 0 0 0 0 8 0 8 % W
% Tyr: 0 0 0 0 8 0 8 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _